When you're playing Binding of Isaac and actually having a good run as the Lost, then you die to something stupid like a fly. I had Holy Mantle too D'x @NickerPan and @RadeonX probably know my pain.
Finishing all the requirements on Hard as The Lost, and still not getting the Godhead because you still have to beat the mom's heart on hard with ???, but you just can't because all items you find are complete feces.
I've never ctied but the saddest moments are: In MW2 when you go through all that work to get that chip thingy for General Shepherd and he shoots you and your teammate (Ghost) then sets you on fire and escapes all smug in his chopper ;_; Also, when my dog died in The Sims 3 (It was a pug ;_; )
I have thin gloves that still keep me warm and they're good for registering the buttons, I can see what you mean though.